There was so little that was written about folding at wikipedia that I speculated a little on my own.
To calculate the folding process. I speculate that its ?similar to checking the engineering strength at every step of the process.
Why. Since a broken molecule is not good for life.
That is. The molecule could be subjected to forces that breaks it apart. It is then smarter to fold in a way that it is ?always structually strong.
So using engineering tools and machine learning it should be possible to in predict the folding changes.